From Earth to Bottle

TSXV: VM OTCQB: VYYRF

Voyageur Pharmaceuticals is the only North American company building a domestic, secure and vertically integrated contrast media drug solution at a cost structure no manufacturer can match.

The Voyageur Advantage

COST ADVANTAGE

93.5%Cost Reduction

Voyageur fully owns the only known pharmaceutical-grade barium deposit in the world. PEA-confirmed production costs are at $650 per tonne, against an industry standard of approximately $10,000 per tonne for synthetic alternatives.

PATENT-PENDING TECHNOLOGY

1stNorth American iodine contrast producer

Fully owned, patent-pending technology enables the first domestic pharmaceutical-grade iodine production with the Mueller process, a technology that extracts iodine from abundant oilfield brine water currently discarded by the oil and gas industry.

ACTIVE COMMERCIAL REVENUE

5 Health Canada licensed barium contrast products

Commercially available with international distributor partnerships across Latin America in place and ongoing Canadian sales revenue as of August 2025.

BAYER PARTNERSHIP

$2.35mUSD milestone based funding

To complete the feasibility study for the Oklahoma iodine extraction facility, with construction fully funded by Bayer, contingent on offtake agreement, with no dilution.

Woman undergoing diagnostic scan with technician preparing the scan

Contrast Media Market

Contrast media are pharmaceutical-grade agents injected or ingested before medical imaging to make internal organs, blood vessels, and tissue visible on X-rays, CT scans, and fluoroscopy.

The Standard Since Inception

Barium and iodine are dense enough to block X-rays and safe enough for the human body, a combination no other elements have matched. Barium and iodine remain the undisputed clinical standard, making them essential and irreplaceable inputs for modern diagnostic imaging.

Growing US$7.3B Market with Limited Supply

Projected to nearly double by 2030 Pharma-grade contrast media is scarce, with foreign supply sitting in unstable jurisdictions and several well-documented instances of shortages amid rising demand.

Proven Innovation, Market Ready

"Capital is selective right now, and it should be.What got my attention with Voyageur is commercial revenue today, Bayer funding the iodine feasibility study, and a firm like Fluor doing the engineering, which is not a typical profile for a company this size. I joined the board because the business has de-risked well ahead of where the valuation sits, and with a cost structure that would be very difficult to match for any synthetic producer in a market this large, it has a credible path to leading the space rather than chasing it."

Jeffrey Kraws

Top 10 global pharma stock picker nearly 20 years, including #1 StarMine, 5-Star biotech & pharma ratings by StarMine; top-rated by Zacks

"As a radiologist, I see every day how essential contrast media are for enabling accurate diagnoses and supporting the best possible care for patients. Reliable access to safe, high-quality contrast agents is vital for healthcare systems, helping ensure that critical imaging examinations can be performed without delay or compromise. Continued innovation and a resilient supply of contrast media are key to meeting the growing demands of modern radiology."

Dr. Thomas Lauenstein

Medical Director at Evangelisches Krankenhaus in Düsseldorf, Germany. Chief physician of radiology since 2015.

"From my decades-long experience as a risk manager, I see that the best-run organizations are those that manage reward and risk intentionally and thoughtfully to achieve valuable strategic objectives. Voyageur's well-constructed project timelines and their sharp focus on internal and external validation of key processes reflect Voyageur's risk-aware culture and commitment to resilient and sustainable product development and execution."

Chris Van Buren

Chris Van Buren

Former CRO at Edward Jones ($2T+ assets, 9M clients) and TIAA ($1T AUM, 4M+ clients), leading enterprise risk management.

5 Licensed Health Canada Products

Two Discoveries, One Supply Chain

A Barium Solution

Frances Creek, a wholly owned deposit in Radium, British Columbia, produces barite at 98.8%+ pharmaceutical purity through a streamlined, cost-effective process. PEA-confirmed production costs at $650 per tonne, against an industry standard of approximately $10,000 per tonne for synthetic alternatives.

An Iodine Solution

The Mueller Process, a patent-pending technology fully owned by Voyageur Pharmaceuticals, extracts pharmaceutical-grade iodine from oilfield brine water using mobile units. Voyageur utilizes North American feedstock that is abundant, broadly distributed, and currently discarded from the oil and gas industry to develop cost–effective, pharmaceutical grade iodine contrast media.

Voyageur’s Path to Production

Barium Timeline

2022

NI 43-101 PEA completed

Independent study by SGS Canada confirmed the Frances Creek resource and production economics.

Q3 2024

Five Health Canada–licensed barium contrast products introduced

SmoothX, SmoothHD, SmoothLD, VisionHD, and VisionLD launched after 18 months of research and development.

Q1 2025

Human clinical testing of barium contrast products completed and clinically accepted

Two-phase testing programme initiated to evaluate clinical safety, imaging quality, and operational efficiency.

Q1 2025

Alberta Innovates $600K grant received

Non-dilutive government funding secured for natural vs. synthetic barium product performance studies and the AICE-Market Access Programme.

Q3 2025

First commercial shipments delivered to Canadian clinics

Full suite of Health Canada–licensed barium contrast products commercially active.

Q4 2025

Latin American distribution agreements secured

Phalanx strategic partnership established to drive market expansion into the Mexican health care sector, specifically in the area of barium-based contrast media.

2026

Barium pre-feasibility study

Third-party engineering validation of Frances Creek production economics, expected to unlock additional approved public claims on cost and resource value.

Q1 2026

Pharmaceutical-grade purity of Frances Creek barite independently confirmed

Third-party testing by SGS Canada verified full USP compliance, successful micronization, and zero base metal contamination for a purity average of 98.8%.

Q2 2026

Permit application submitted for Frances Creek barium extraction

Multi-year bulk sample of 2,000 annual tonnes; 5-year extraction permit filed for Frances Creek. Approval expected Q4 2026 to support fully integrated, cost-effective barium contrast production.

Q2 2026

Three US manufacturing locations under evaluation

Competitive site selection underway for the integrated iodine and barium contrast media facility.

Q4 2026

Frances Creek bulk sample permit approved and sampling initiated

Approval of the submitted 5-year permit enables extraction of up to 2,000 tonnes per year, providing physical supply for product manufacturing and further validating the resource at commercial scale.

2027

US manufacturing site location selection

Subject to ongoing discussions and economic incentives with three US municipalities.

2027

US FDA approval for barium contrast products

Regulatory clearance in the US market opens access to North America's largest contrast media-consuming market, which currently has no domestic barium supplier.

Q1 2027

Health Canada clinical trial completed using Frances Creek barite API

Successful trial completion is the final bridge to substituting Frances Creek natural barium into existing licensed products, replacing the synthetic input and leveraging the full cost advantage.

2028–2029

Integrated North American manufacturing facility construction commences

The Earth-to-Bottle facility, combining Frances Creek barium and domestically extracted iodine into finished contrast drugs, begins construction, subject to site selection and capex financing secured.

2029+

Frances Creek mine in full production

With bulk sampling complete and the pre-feasibility study validated, the Frances Creek mine transitions to full operational status, activating the $650/tonne production cost advantage subsequent to securing capex financing.

2029+

North American market share capture in barium contrast

With domestic supply, a 15x cost advantage over synthetic alternatives, and FDA approval in hand, Voyageur enters a market currently monopolised by a single importer, offering hospitals a domestic alternative for the first time.

2029+

NYSE American uplisting

As revenue scales and the US asset base grows, management has indicated a target dual listing from the TSXV to the NYSE, materially expanding the investor base and institutional access.

Iodine Timeline

Q4 2024

LOI signed with Bayer

Letter of intent signed with a large multinational pharmaceutical company, initiating the iodine collaboration that would become the formal funding agreement.

Q1 2026

Mueller Process IP secured

Secured 100-per-cent ownership to an innovative iodine extraction technology developed by Dr. Brian Mueller, PhD, who has been appointed as the company's director of chemistry.

Q1 2026

Bayer collaboration agreement signed

USD $2.35 million in milestone based funding committed to complete the feasibility study for the Oklahoma iodine extraction facility.

2026

Voyageur internal iodine drug production pre-feasibility publication

Study will highlight proprietary manufacturing cost savings, translating to high-margin financial projections for finished iodine contrast media.

Q2 2026

Fluor Corporation engaged

Leading global engineering firm retained to complete dual feasibility studies: the Iodine Project as part of a collaboration with Bayer, and Voyageur's Integrated Iodine and Barium Contrast Drug Manufacturing Facility, projected early 2027 completion date.

Q2 2026

Three US manufacturing locations under evaluation

Competitive site selection underway for the integrated iodine and barium contrast media facility.

Q4 2026

Bayer offtake-linked financing agreement

Subject to the ongoing feasibility engagement, Bayer may negotiate the Offtake Agreement for iodine prill production resulting from the project. All intellectual property and infrastructure developed in connection with the project will remain exclusively owned by Voyageur.

Early 2027

Dual feasibility studies complete

Fluor-led studies for the Oklahoma iodine facility and integrated manufacturing plant.

2027

US manufacturing site location selection

Subject to ongoing discussions and economic incentives with three US municipalities.

2028

Oklahoma iodine extraction facility operational

Construction and commissioning of the first commercial-scale, pharmaceutical grade iodine prill manufacturing facility in North America. Construction fully funded by Bayer, contingent on offtake agreement, with no dilution.

2028–2029

First US iodine contrast drug approvals

FDA pathway for iodine contrast products developed via the Streamline Process, positioning Voyageur as the first domestic US producer of iodine contrast, a category currently 100% import-dependent.

2028–2029

Integrated North American manufacturing facility construction commences

The Earth-to-Bottle facility combining Frances Creek barium and domestically extracted iodine into finished contrast drugs begins construction, subject to site selection and capex financing secured.

Long-term

Iodine contrast market entry at scale

As the integrated manufacturing facility reaches capacity, Voyageur becomes a full-scale North American producer of both barium and iodine contrast media, the only vertically integrated Earth-to-Bottle supplier in the world.

Management Proxy Materials

MANAGEMENT’S DISCUSSION & ANALYSIS

NOTICE AND INFORMATION CIRCULAR

NOTICE AND ACCESS

FINANCIAL STATEMENTS


– NOVEMBER 2024

FORM OF PROXY – COMMON SHARES

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Disclaimer & Compliance Disclosures

Forward-Looking Information & Financial/Economic Projections:

The contents of this webpage include forward-looking statements regarding future operations, regulatory approvals, project timelines, cost structure advantages, and market growth potential. Forward-looking statements are based on current management estimates and are subject to significant risks, uncertainties, and assumptions. Economic metrics regarding the Frances Creek project—including PEA-confirmed production cost estimates ($650/tonne), net present value ($344M NPV), project cash flow ($630M), total capital expenditures ($36M CAPEX), internal rate of return (137% IRR), and total USP barium resource estimates (130,000 tonnes)—are sourced directly from the Preliminary Economic Assessment (PEA) titled “Preliminary Economic Assessment for the Frances Creek Barite Deposit,” prepared by SGS Canada Inc. (dated February 22, 2022). Projected margins and production cost reductions reflect preliminary economic models; actual commercial results remain contingent upon completing pre-feasibility studies, feasibility studies, capital financing, regulatory clearances, and mine development.

Strategic Collaboration & Funding Disclosures:

References to strategic funding for the Oklahoma iodine extraction facility reflect the non-dilutive milestone framework agreed upon with Bayer AG (totaling up to USD $2.35 million). Commercial-scale plant construction, long-term supply arrangements, and product manufacturing remain subject to the successful completion of feasibility studies and the execution of a binding long-term offtake agreement. All intellectual property and infrastructure developed under the collaboration remain exclusively owned by Voyageur Pharmaceuticals Ltd.

Third-Party Data & Market Claims:

Industry data, market projections (including global contrast media market growth forecasts), diagnostic imaging volumes, and historical pricing trends (such as contrast media price increases of over 303% since 2017 and foreign synthetic barite import benchmarks of ~$10,000/tonne) are derived from independent third-party market research (including Grand View Research, PricePedia, and GE HealthCare estimates), public regulatory databases (Health Canada and US FDA), and the US Geological Survey (USGS).

General Securities & Regulatory Disclaimer:

This webpage is provided for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy any securities in Canada, the United States, or any other jurisdiction. Neither the TSX Venture Exchange, the OTC Markets Group, nor any securities regulatory authority has approved or disapproved the contents of this webpage.